How does modaifnil work in the brain Essay Example | Topics and Well Written Essays - 750 words

How does modaifnil work in the brain - Essay Example Side effects that are common in CNS stimulants but are not observed in Modafinil users include arterial hypertension and tachycardia. The absence of these effects has been widely attributed to the drug’s mechanism of action, though the exact principles of this yet to be established. The paper will focus on the positive effects of the drug and its pharmacokinetics on neural activity. There have been several theories formulated on the mechanism of neurostimuation by Modafinil. Among these include the histamine effect and the increment of the neurotransmitter dopamine by inhibiting its uptake therefore leaving sufficient amounts for transmission of neurosynaptic impulses. However, theories have suggested that the involvement of dopamine in this action is minimal; hence the different side effects (Saletu &Saletu-Zyhlarz, 2013, 231). The drug is also assumed to increase the availability of other neurotransmitters such as norepinephrine. These mechanisms will be explained in detail in the following section. Among the numerous theories that have been formulated, one that is most indicative from the author’s research findings is the theory suggesting interaction and activity of Reticular Activating System neurons in the rhombencephalon with Modanifil (Rasetti et al., 2010, 2101-2109). These neurons have been found to be responsible for sustaining arousal levels in humans. The drug has a different impact on the RAS than other neurostimulators such as amphetamine and methylphenitade. Researchers have stated that effects of this drug on the above mentioned structures involve glutamate, hypocretin, ?-aminobutyric acid, norepinephrine, epinephrine, histamine and dopamine (Rasetti et al., 2010, 2101-2109). Modafinil has been found to increase the synthesis and release of norepinephrin by altering activity in the locus coeruleus to low tonic and high phasic (Volkow et al., 2009, 1148-1154). The drug possesses an agonistic effect on alpha 1 adrenergic receptors; hence it has a direct stimulatory effect resulting in the inhibition of norepinephrine uptake (Saletu &Saletu-Zyhlarz, 2013, 231). Therefore, this neurotransmitter is increased and has positive impacts on several centers of the brain promoting wakefulness. Some of the effects that occur as a result of increased norepinephrine include increased memory, cerebral plasticity and learning and attention. It also stimulates the Autonomic nervous system, particularly the sympathetic, and increases heart rate and blood pressure leading to enhanced levels of energy (Saletu &Saletu-Zyhlarz, 2013, 231). Another mechanism that has been suggested involves the elevation in histamine levels. This is due to the effect of Modafinil on receptors of neurons containing peptides which are known as orexins. Specifically these receptors are known as orexin 1 and 2 (Rasetti et al., 2010, 2101-2109). These neurons radiate to different parts of the cerebral cortex, and have been found to also influence center s of involved in sustaining arousal levels and wakefulness. These neurons have also been found to increase the level of neurotransmitters such as noradrenalin and dopamine in the above mentioned areas (Volkow et al., 2009, 1148-1154). The involvement of dopamine in the effects of Modafinil will be explained further in the paper. The above mentioned orexin neurons activated by Modafinil also affect and

Workplace negotiation Research Paper Example | Topics and Well Written Essays - 1500 words

Workplace negotiation - Research Paper Example The success of negotiations in the workplace is usually depended on the willingness of the parties to arrive to commonly accepted solutions, meaning that the decisions made should respond to the interests of all participants. The collective bargaining systems have been introduced in order to help towards the improvement of communication between employers and employees – referring to both the private and the public sector (Adams 1999). However, the above target is not always achieved. In this way, the value of collective bargaining, as a tool for communication/ cooperation in regard to the employers’ and the employees’ rights is reduced. The reasons for the failure of statutory collective bargaining systems in promoting collective bargaining are presented and analyzed in this paper. Reference is made, as indicative examples, to two Anglo-Saxon countries, US and Australia. It is proved that the statutory collective bargaining systems in countries with common legal environment are likely to present similar weaknesses; the characteristics of a country’s legal framework are therefore of critical importance for the prospects of the particular country’s statutory collective bargaining systems (Davidov 2004). ... This fact is revealed in the Wagner Act of 1935, the legislative text incorporating the criteria for the establishment and the expansion of collective bargaining in USA. The above Act has a critical weakness: it emphasizes on the process of establishing a relationship between the union and the worker – meaning that the employees recognize a particular union as their representative in the bargaining process – and on ensuring that the bargaining process begins (Cox et al. 1950, p.389). No reference is made to the principles or the methodologies on which the collective bargaining process will be based. In this way, it is possible that violations of the rights of either of the parties are taken place since no standards or requirements are set for the development of the process (Cox et al. 1950, p.389). The above phenomenon is, still today, a key characteristic of the collective bargaining process in USA showing the gaps of the legislation in the specific field. In accordanc e with Cox et al. (1950) the above trend could be possibly explained by the following fact: since their appearance, unions have managed to increase their power. In fact, the growth of unions has been continuous and impressive causing strong pressures to the markets globally. For this reason, it is implied that no support is required to the collective bargaining process, as a procedure in progress; rather, emphasis should be made on the protection of the process as a tool for communication between employers and employees. In other words, since trade unions exist in a particular country and since the access of employees to them is secured, then no further action should be taken for the promotion of unionism and collective bargaining. This is the idea on which the